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GeneBench

Paper

Progress Over Time

Interactive timeline showing model performance evolution on GeneBench

State-of-the-art frontier
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GeneBench Leaderboard

2 models
ContextCostLicense
1
OpenAI
GPT-5.5 Pro
OpenAI
———
2
OpenAI
GPT-5.5
OpenAI
—1.1M$5.00 / $30.00
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Sub-benchmarks

GeneBench-Pro

GeneBench-Pro is a research-level benchmark of 129 multi-stage computational-biology problems spanning genomics, quantitative biology, and translational biomedicine. Each problem gives the agent a messy dataset, brief context, and a target estimand, and requires navigating dependent inferential decision points to reach a verifiable answer.

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About this benchmark

What is GeneBench?

GeneBench is an evaluation focused on multi-stage scientific data analysis in genetics and quantitative biology. Tasks require reasoning about ambiguous or noisy data with minimal supervisory guidance, addressing realistic obstacles such as hidden confounders or QC failures, and correctly implementing and interpreting modern statistical methods.

GeneBench is a text benchmark evaluating models on reasoning, science, and agents tasks. LLM Stats tracks 2 models on this benchmark, scored on a 0–1 scale. The current average is 0.3, with the leader at 0.3.

Compare leaders on the best AI for reasoning, best AI for science and best AI for agents leaderboards.

Current leaders

GPT-5.5 Pro from OpenAI currently leads the GeneBench leaderboard with a score of 0.332 across 2 evaluated AI models.

1GPT-5.5 ProOpenAI33.2%
2GPT-5.5OpenAI25.0%

FAQ

Common questions about the GeneBench benchmark and leaderboard.

What is the GeneBench benchmark?

GeneBench is an evaluation focused on multi-stage scientific data analysis in genetics and quantitative biology. Tasks require reasoning about ambiguous or noisy data with minimal supervisory guidance, addressing realistic obstacles such as hidden confounders or QC failures, and correctly implementing and interpreting modern statistical methods.

What is the GeneBench leaderboard?

The GeneBench leaderboard ranks 2 AI models based on their performance on this benchmark. Currently, GPT-5.5 Pro by OpenAI leads with a score of 0.332. The average score across all models is 0.291.

What is the highest GeneBench score?

The highest GeneBench score is 0.332, achieved by GPT-5.5 Pro from OpenAI.

How many models are evaluated on GeneBench?

2 models have been evaluated on the GeneBench benchmark, with 0 verified results and 2 self-reported results.

Where can I find the GeneBench paper?

The GeneBench paper is available at https://cdn.openai.com/pdf/6dc7175d-d9e7-4b8d-96b8-48fe5798cd5b/oai_genebench_benchmark.pdf. The paper details the methodology, dataset construction, and evaluation criteria.

What categories does GeneBench cover?

GeneBench is categorized under reasoning, science, and agents. The benchmark evaluates text models.

Are there variants of GeneBench?

Yes. GeneBench has 1 related variant: GeneBench-Pro.

How recent are the GeneBench leaderboard results?

The GeneBench leaderboard was last updated in July 2026 and currently includes 2 evaluated models.