De novo protein binder design
Progress Over Time
Interactive timeline showing model performance evolution on De novo protein binder design
De novo protein binder design Leaderboard
| Context | Cost | License | ||||
|---|---|---|---|---|---|---|
| 1 |  Anthropic | — | 1.0M | $2.00 / $10.00 |
What is De novo protein binder design?
De novo protein binder design: for each of 15 protein targets, design a set of 30 miniprotein binders within a fixed 24-hour wall-clock budget given the target structure.
De novo protein binder design is a text benchmark evaluating models on science, agents, and biology tasks. LLM Stats tracks 1 models on this benchmark, scored on a 0–1 scale. The current average is 0.8, with the leader at 0.8.
Compare leaders on the best AI for science, best AI for agents and best AI for biology leaderboards.
Current leaders
Claude Sonnet 5.5 from Anthropic currently leads the De novo protein binder design leaderboard with a score of 0.823 across 1 evaluated AI models.
FAQ
Common questions about the De novo protein binder design benchmark and leaderboard.