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Claude Opus 5 vs MedGemma 4B IT

Claude Opus 5 leads the LLM Stats Score 54.6 to -4.5.

Anthropic · Google · Updated for 2026

Which is better?

Claude Opus 5 leads the overall LLM Stats Score 54.6 to -4.5, ranking #5 overall.

Based on current LLM Stats indexes, shared benchmarks, pricing, and model metadata for 2026.

Choose Claude Opus 5

  • overall performance matters — it scores 54.6 and ranks #5 on LLM Stats
  • your work emphasizes reasoning — it leads those capability indexes
  • you want the most recent training data — it shipped Jul 2026

Choose MedGemma 4B IT

  • you need open weights you can self-host or fine-tune

At a glance

The differences that matter most.

Claude Opus 5
Anthropic
MedGemma 4B IT
Google
Core performance indexes
LLM Stats Score
54.6
#5
-4.5
#352
Reasoning
53.5
#4
-5.0
#349
Cost, coverage & limits
Benchmark wins
—
—
Input price
$5.00 / M
— / M
Output price
$25.00 / M
— / M
Context window
1,000,000
—

Capability indexes

Additional strengths measured across groups of related public benchmarks

1 shared
Index
Claude Opus 5
MedGemma 4B IT
Vision
37.9#4
-6.8#204
Conservative TrueSkill rating · higher is betterHow scores work

Individual benchmarks

13 reported for Claude Opus 5 · 7 for MedGemma 4B IT

No common benchmarks found

Claude Opus 5 and MedGemma 4B ITdon't have any common benchmark datasets to compare. They may have been evaluated on different testing suites.

Human preference

Blind head-to-head votes and playground preference scores

Context Window

Maximum input and output token capacity

Only Claude Opus 5 specifies input context (1,000,000 tokens). Only Claude Opus 5 specifies output context (128,000 tokens).

Anthropic
Claude Opus 5
Input1,000,000 tokens
Output128,000 tokens
Google
MedGemma 4B IT
Input- tokens
Output- tokens
Tue Sep 22 2026 • llm-stats.com

Input capabilities

Documented input modalities across available providers

Both Claude Opus 5 and MedGemma 4B IT support multimodal inputs.

They are both capable of processing various types of data, offering versatility in application.

Claude Opus 5

Text
Images
Audio
Video

MedGemma 4B IT

Text
Images
Audio
Video

License

Usage and distribution terms

Claude Opus 5 is licensed under a proprietary license, while MedGemma 4B IT uses Health AI Developer Foundations terms of use.

License differences may affect how you can use these models in commercial or open-source projects.

Claude Opus 5

Proprietary

Closed source

MedGemma 4B IT

Health AI Developer Foundations terms of use

Open weights

Release Timeline

When each model was launched

Claude Opus 5 was released on 2026-07-24, while MedGemma 4B IT was released on 2025-05-20.

Claude Opus 5 is 14 months newer than MedGemma 4B IT.

Claude Opus 5

Jul 24, 2026

2 months ago

1.2yr newer
MedGemma 4B IT

May 20, 2025

1.3 years ago

Knowledge Cutoff

When training data ends

Neither model specifies a knowledge cutoff date.

Unable to compare the recency of their training data.

No cutoff dates available

Outputs Comparison

Notice missing or incorrect data?Start an Issue discussion→

Judge for yourself.

Run your own prompts against Claude Opus 5 and MedGemma 4B IT side-by-side, then vote on the output you prefer.

Claude Opus 5
✓ Preferred
MedGemma 4B IT
Open in Playground

FAQ

Common questions about Claude Opus 5 vs MedGemma 4B IT.

Which is better, Claude Opus 5 or MedGemma 4B IT?

Claude Opus 5 leads the LLM Stats Score 54.6 to -4.5. Claude Opus 5 is made by Anthropic and MedGemma 4B IT is made by Google. The best choice depends on your use case — compare their capability indexes, individual benchmarks, pricing, and limits above.

How does Claude Opus 5 compare to MedGemma 4B IT in benchmarks?

Claude Opus 5 scores BrowseComp: 90.8%, BioMysteryBench: 90.1%, OSWorld 2.0: 70.6%, DeepSWE 1.1: 68.8%, Humanity's Last Exam: 64.7%. MedGemma 4B IT scores MIMIC CXR: 88.9%, DermMCQA: 71.8%, PathMCQA: 69.8%, SlakeVQA: 62.3%, VQA-Rad: 49.9%.

What are the context window sizes for Claude Opus 5 and MedGemma 4B IT?

Claude Opus 5 supports 1.0M tokens and MedGemma 4B IT supports an unknown number of tokens. A larger context window lets you process longer documents, conversations, or codebases in a single request.

What are the main differences between Claude Opus 5 and MedGemma 4B IT?

Key differences include LLM Stats Score (54.6 vs -4.5), licensing (Proprietary vs Health AI Developer Foundations terms of use). See the full comparison above for benchmark-by-benchmark results.

Who makes Claude Opus 5 and MedGemma 4B IT?

Claude Opus 5 is developed by Anthropic and MedGemma 4B IT is developed by Google.

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