Model Comparison

Claude Opus 4.5 vs MedGemma 4B ITWhich is better in 2026?

Comparing Claude Opus 4.5 and MedGemma 4B IT across benchmarks, pricing, and capabilities.

Verdict: Claude Opus 4.5 vs MedGemma 4B IT — which is better?

Claude Opus 4.5 (by Anthropic) and MedGemma 4B IT (by Google) are two of the AI models people compare most. Here is how they stack up on benchmarks, price and capabilities, and which one to pick in 2026.

Choose Claude Opus 4.5 if…

  • you want the most recent training data — it shipped Nov 2025

Choose MedGemma 4B IT if…

  • you need open weights you can self-host or fine-tune
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Performance Benchmarks

Comparative analysis across standard metrics

No common benchmarks found

Claude Opus 4.5 and MedGemma 4B ITdon't have any common benchmark datasets to compare. They may have been evaluated on different testing suites.

Arena Performance

Human preference votes

Context Window

Maximum input and output token capacity

Only Claude Opus 4.5 specifies input context (200,000 tokens). Only Claude Opus 4.5 specifies output context (64,000 tokens).

Anthropic
Claude Opus 4.5
Input200,000 tokens
Output64,000 tokens
Google
MedGemma 4B IT
Input- tokens
Output- tokens
Wed Jun 24 2026 • llm-stats.com

Input Capabilities

Supported data types and modalities

Both Claude Opus 4.5 and MedGemma 4B IT support multimodal inputs.

They are both capable of processing various types of data, offering versatility in application.

Claude Opus 4.5

Text
Images
Audio
Video

MedGemma 4B IT

Text
Images
Audio
Video

License

Usage and distribution terms

Claude Opus 4.5 is licensed under a proprietary license, while MedGemma 4B IT uses Health AI Developer Foundations terms of use.

License differences may affect how you can use these models in commercial or open-source projects.

Claude Opus 4.5

Proprietary

Closed source

MedGemma 4B IT

Health AI Developer Foundations terms of use

Open weights

Release Timeline

When each model was launched

Claude Opus 4.5 was released on 2025-11-24, while MedGemma 4B IT was released on 2025-05-20.

Claude Opus 4.5 is 6 months newer than MedGemma 4B IT.

Claude Opus 4.5

Nov 24, 2025

7 months ago

6mo newer
MedGemma 4B IT

May 20, 2025

1.1 years ago

Knowledge Cutoff

When training data ends

Claude Opus 4.5 has a documented knowledge cutoff of 2025-03-31, while MedGemma 4B IT's cutoff date is not specified.

We can confirm Claude Opus 4.5's training data extends to 2025-03-31, but cannot make a direct comparison without MedGemma 4B IT's cutoff date.

Claude Opus 4.5

Mar 2025

MedGemma 4B IT

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Outputs Comparison

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Key Takeaways

Anthropic
Larger context window (200,000 tokens)
Google
Has open weights

Detailed Comparison

AI Model Comparison Table
Feature
Anthropic
Claude Opus 4.5
Google
MedGemma 4B IT

FAQ

Common questions about Claude Opus 4.5 vs MedGemma 4B IT.

Which is better, Claude Opus 4.5 or MedGemma 4B IT?

Claude Opus 4.5 (Anthropic) and MedGemma 4B IT (Google) each have strengths in different areas. Compare their benchmark scores, pricing, context windows, and capabilities above to determine which fits your needs.

How does Claude Opus 4.5 compare to MedGemma 4B IT in benchmarks?

Claude Opus 4.5 scores Tau2 Telecom: 98.2%, MMMLU: 90.8%, Tau2 Retail: 88.9%, GPQA: 87.0%, SWE-Bench Verified: 80.9%. MedGemma 4B IT scores MIMIC CXR: 88.9%, DermMCQA: 71.8%, PathMCQA: 69.8%, SlakeVQA: 62.3%, VQA-Rad: 49.9%.

What are the context window sizes for Claude Opus 4.5 and MedGemma 4B IT?

Claude Opus 4.5 supports 200K tokens and MedGemma 4B IT supports an unknown number of tokens. A larger context window lets you process longer documents, conversations, or codebases in a single request.

What are the main differences between Claude Opus 4.5 and MedGemma 4B IT?

Key differences include licensing (Proprietary vs Health AI Developer Foundations terms of use). See the full comparison above for benchmark-by-benchmark results.

Who makes Claude Opus 4.5 and MedGemma 4B IT?

Claude Opus 4.5 is developed by Anthropic and MedGemma 4B IT is developed by Google.

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